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SML3544

Sigma-Aldrich

Ginsenoside Ro

≥94% (HPLC)

Synonym(s):

(3β)-28-(β-D-Glucopyranosyloxy)-28-oxoolean-12-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranosiduronic acid, Chikusetsusaponin 5, Polysciasaponin P3

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About This Item

Empirical Formula (Hill Notation):
C48H76O19
CAS Number:
Molecular Weight:
957.11
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥94% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

InChI

1S/C48H76O19/c1-43(2)14-16-48(42(61)67-40-35(58)31(54)29(52)24(20-50)63-40)17-15-46(6)21(22(48)18-43)8-9-26-45(5)12-11-27(44(3,4)25(45)10-13-47(26,46)7)64-41-37(33(56)32(55)36(65-41)38(59)60)66-39-34(57)30(53)28(51)23(19-49)62-39/h8,22-37,39-41,49-58H,9-20H2,1-7H3,(H,59,60)/t22-,23+,24+,25-,26+,27-,28+,29+,30-,31-,32-,33-,34+,35+,36-,37+,39-,40-,41+,45-,46+,47+,48-/m0/s1

InChI key

NFZYDZXHKFHPGA-QQHDHSITSA-N

Biochem/physiol Actions

Ginsenoside Ro is a key constituent of ginseng that exhibits varies health beneficial activities including antitumor, anti-inflammatory, and antioxidant. Ginsenoside Ro ameliorates obesity and insulin resistance in high fat diet-induced obese (DIO) mice without affecting food intake through activation of G protein-coupled bile acid receptor 5 (TGR5).

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Ginsenoside Ro Ameliorates High-Fat Diet-Induced Obesity and Insulin Resistance in Mice via Activation of the G Protein-Coupled Bile Acid Receptor 5 Pathway
Journal of Pharmacology and Experimental Therapeutics, 377, 441-451 (2021)

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