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SML2422

Sigma-Aldrich

Sophocarpine

≥95% (HPLC)

Synonym(s):

(-)-Sophocarpine, 13,14-Didehydromatridin-15-one, SC

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25 MG
R 710,50
125 MG
R 2 165,80

R 710,50

List PriceR 725,00
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25 MG
R 710,50
125 MG
R 2 165,80

About This Item

Empirical Formula (Hill Notation):
C15H22N2O
CAS Number:
6483-15-4
Molecular Weight:
246.35
MDL number:
MFCD00274555
UNSPSC Code:
12352200

R 710,50

List PriceR 725,00
Please contact Customer Service for Availability
Request a Bulk Order

biological source

Sophora alopecuroides

Assay

≥95% (HPLC)

form

powder

optical activity

[α]/D -26 to -35°, c = 0.5 in ethanol

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

[Br-].N21[C@@H]3[C@@H]([C@@H]4N(C[C@@H]3CCC2)C(=O)C=CC4)CCC1.[H+]

InChI

1S/C15H22N2O.BrH/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14;/h1,7,11-13,15H,2-6,8-10H2;1H/t11-,12+,13+,15-;/m0./s1

InChI key

NBBQEIQEBNYSFK-PUILLJIJSA-N

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Biochem/physiol Actions

Sophocarpine is a natural product found to have anti-inflammatory, anti-cancer, and antiviral activity. Sophocarpine was active in an mouse xenograft model. It inhibited growth of head and neck squamous cell carcinomas by downregulation of miR-21 expression. Sophocarpine was also shown to protecs mice from a form of hepatitis by inhibiting the IFNg/STAT1 pathway.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000126494
0000126495
0000120347
0000068921
0000068922

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Genhuan Yang et al.
Annals of palliative medicine, 9(4), 1622-1630 (2020-06-13)
Cigarette smoking is one of the main predisposing factors for atherosclerosis, which can lead to vascular inflammation. Emerging research has demonstrated that the rate of restenosis is increased following angioplasty in smokers. Sophocarpine, one of the Sophora alkaloids, can play

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