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SML2398

Sigma-Aldrich

SR16832

≥98% (HPLC)

Synonym(s):

2-Chloro-N-(6-methoxyquinolin-4-yl)-5-nitrobenzamide

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5 MG
R 1 252,44
25 MG
R 5 073,46

R 1 252,44

List PriceR 1 278,00
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5 MG
R 1 252,44
25 MG
R 5 073,46

About This Item

Empirical Formula (Hill Notation):
C17H12ClN3O4
CAS Number:
2088135-12-8
Molecular Weight:
357.75
UNSPSC Code:
12352200
NACRES:
NA.77

R 1 252,44

List PriceR 1 278,00
Please contact Customer Service for Availability
Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

ClC1=CC=C([N+]([O-])=O)C=C1C(NC2=C(C=C(OC)C=C3)C3=NC=C2)=O

InChI

1S/C17H12ClN3O4/c1-25-11-3-5-15-13(9-11)16(6-7-19-15)20-17(22)12-8-10(21(23)24)2-4-14(12)18/h2-9H,1H3,(H,19,20,22)

InChI key

CVTZAGCRUDYUGB-UHFFFAOYSA-N

Biochem/physiol Actions

PPARγ antagonist
SR16832 is a PPARγ antagonist. It acts as a dual-site covalent inhibitor of PPARγ inhibiting both orthosteric and allosteric cellular activation by the PPARγ agonists.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Richard Brust et al.
ACS chemical biology, 12(4), 969-978 (2017-02-07)
GW9662 and T0070907 are widely used commercially available irreversible antagonists of peroxisome proliferator-activated receptor gamma (PPARγ). These antagonists covalently modify Cys285 located in an orthosteric ligand-binding pocket embedded in the PPARγ ligand-binding domain and are used to block binding of

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