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Key Documents

SML2344

Sigma-Aldrich

SJB3-019A

≥98% (HPLC)

Synonym(s):

2-(Pyridin-3-yl)napthalo(-2,3-d)oxazole-4,9-dione

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5 MG
R 1 519,00

R 1 519,00

List PriceR 1 550,00

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5 MG
R 1 519,00

About This Item

Empirical Formula (Hill Notation):
C16H8N2O3
CAS Number:
Molecular Weight:
276.25
UNSPSC Code:
12352200
NACRES:
NA.77

R 1 519,00

List PriceR 1 550,00

Please contact Customer Service for Availability

Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

color

white to very dark gray

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

potent USP1 inhibitor that induces ID1 degradation, upregulation of p21 and cytoxicity in K562 and other leukemic cell lines

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Helena Mistry et al.
Molecular cancer therapeutics, 12(12), 2651-2662 (2013-10-17)
Inhibitor of DNA binding 1 (ID1) transcription factor is essential for the proliferation and progression of many cancer types, including leukemia. However, the ID1 protein has not yet been therapeutically targeted in leukemia. ID1 is normally polyubiquitinated and degraded by

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