AEG 3482 is an imidazothiadiazole sulfonamide of 281 D with an anti-apoptotic property.[1]
AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis.
AEG3284 is an indirect inhibitor of JNK activity; HSP90 binder.
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This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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