Anti-GAD1 antibody detects endogenous levels of total GAD1 protein.
GAD1 gene (glutamate decarboxylase 1) codes for a glutamic acid decarboxylase enzyme (GAD67), that is of 67 kDa. It is mapped to human chromosome 2q31.1.
Immunogen
The antiserum was produced against synthesized peptide derived from human GAD1.
Immunogen Range: 471-520
Biochem/physiol Actions
GAD1 gene (glutamate decarboxylase 1) participates in GABA (γ-aminobutyric acid) synthesis. Variations in GAD1 results in hyperactivity in attention-deficit/hyperactivity disorder. It is also characterized with childhood-onset schizophrenia and cortical gray matter volume loss.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
GAD1 gene polymorphisms are associated with hyperactivity in Attention-Deficit/Hyperactivity Disorder
Bruxel EM, et al.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 171(8), 1099-1104 (2016)
GAD1 Gene Expression in Blood of Patients with First-Episode Psychosis
Yee JY, et al.
PLoS ONE, 12(1), e0170805-e0170805 (2017)
GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss.
Addington AM, et al.
Molecular Psychiatry, 10(6), 581-588 (2005)
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