Leucine-rich repeat protein SHOC-2 is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and is cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade.
Immunogen
SHOC2 antibody was raised against a 21 amino acid peptide near the amino terminus of human SHOC2.
Biochem/physiol Actions
Leucine-rich repeat protein SHOC2 participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. SHOC2, together with protein phosphatase 1c (PP1c), forms a highly specific M-Ras effector complex and is essential for the activation of MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.
Features and Benefits
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Linkage
The action of this antibody can be blocked using blocking peptide SBP3500051.
Physical form
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
Mutation in SHOC2 promotes aberrant protein N-myristoylation and underlies Noonan-like syndrome with loose anagen hair
Viviana Cordeddu
Nature Genetics, 41(9), 1022-1026 (2009)
Noonan syndrome-like disorder with loose anagen hair: a second case with neuroblastoma.
Garavelli L
American Journal of Medical Genetics. Part A, 167A(8), 1902-1907 (2015)
soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling
Laura M
Proceedings of the National Academy of Sciences of the USA, 95(12), 6903-6908 (1998)
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