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SAB1403984

Sigma-Aldrich

Monoclonal Anti-INSRR antibody produced in mouse

clone 5C6, purified immunoglobulin, buffered aqueous solution

Synonym(s):

IRR

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100 μG
R 8 833,72

R 8 833,72

List PriceR 9 014,00
Please contact Customer Service for Availability
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100 μG
R 8 833,72

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

R 8 833,72

List PriceR 9 014,00
Please contact Customer Service for Availability

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

5C6, monoclonal

form

buffered aqueous solution

mol wt

antigen ~38.1 kDa

species reactivity

human, rat

technique(s)

capture ELISA: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

NCBI accession no.

NM_014215

UniProt accession no.

P14616

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... INSRR(3645)

General description

Mouse monoclonal antibody raised against a partial recombinant INSRR.
The gene INSRR (insulin receptor related receptor) is mapped to human chromosome 1q21-q23. It belongs to the insulin receptor family of proteins. INSRR is mainly present in organs which are associated with acid/base generation. The protein has two N-terminal leucine-rich repeat domains, a cysteine-rich C domain and three C-terminal fibronectin type-III repeats.

Immunogen

INSRR (NP_055030, 651 a.a. ~ 760 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
LYLNDYCHRGLRLPTSNNDPRFDGEDGDPEAEMESDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNAITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDF

Biochem/physiol Actions

INSRR (insulin receptor related receptor) exhibits pH-sensing property and is a sensor for mild alkaline extracellular medium. In mice, it is associated with excessive excretion of base by the kidneys.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
06153-5C6

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The protein tyrosine kinase family of the human genome.
Robinson DR, et al.
Oncogene, 19, 5548-5557 (2000)
Mapping of alkali-sensing sites of the insulin receptor-related receptor. The role of L2 and fibronectin domains.
Deyev IE
Biochimie, 111, 1-9 (2015)

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