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SAB1307046

Sigma-Aldrich

ANTI-APCDD1(N-TERMINAL) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

APCDD1, Adenomatosis polyposis coli down-regulated 1 protein, DRAPC1, Protein APCDD1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

58797 Da

species reactivity

human

technique(s)

immunohistochemistry: 1:10-1:50
western blot: 1:1000

NCBI accession no.

NP_694545.1

UniProt accession no.

Q8J025

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APCDD1(147495)

General description

Adenomatosis polyposis coli down-regulated 1 (APCDD1) encodes a membrane bound glycoprotein. Apcdd1 is predominantly expressed in epidermal and dermal compartments of human hair follicles. In human chromosome, the gene APCDD1 is localized on 18p11.22.

Biochem/physiol Actions

Adenomatosis polyposis coli down-regulated 1 (APCDD1) inhibits wnt (wingless/integrated) signalling and promotes human hair growth. Mutations in APCDD1 results in a rare autosomal dominant hereditary hypotrichosis, which is characterized by hair loss due to hair follicle miniaturization. APCDD1 is directly regulated by β-catenin/T-cell factor 4 (TCF4). The high expression of Apcdd1 in colon cancer cells promotes its proliferation. APCDD1 is essential for adipocyte differentiation. Downregulation of APCDD1 in diet induced obesity impairs adipocyte differentiation and causes obesity related metabolic diseases.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Novel role for Wnt inhibitor APCDD1 in adipocyte differentiation: implications for diet-induced obesity
Yiew NKH, et al.
The Journal of Biological Chemistry, jbc-M116 (2017)
Yutaka Shimomura et al.
Nature, 464(7291), 1043-1047 (2010-04-16)
Hereditary hypotrichosis simplex is a rare autosomal dominant form of hair loss characterized by hair follicle miniaturization. Using genetic linkage analysis, we mapped a new locus for the disease to chromosome 18p11.22, and identified a mutation (Leu9Arg) in the adenomatosis
Meiko Takahashi et al.
Cancer research, 62(20), 5651-5656 (2002-10-18)
To clarify the molecular mechanisms of human carcinogenesis associated with abnormal beta-catenin/T-cell factor (Tcf) signaling, we have been using cDNA microarrays to search for genes whose expression is significantly altered after introduction of wild-type APC into SW480 colon cancer cells.

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