The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and mental retardation. The gene for DSCR4 is found in this region and multiple transcripts may exist. It is mainly expressed in the placenta.
Immunogen
DSCR4 (NP_005858, 89-124) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DSCR4.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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