S0575

Anti-SET (56-70) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(s): Anti-2PP2A, Anti-I2PP2A, Anti-IGAAD, Anti-IPP2A2, Anti-PHAPII, Anti-SET Isoform 2 of Protein SET, Anti-TAF-I, Anti-TAF-Iβ
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~32 kDa
• species reactivity: human
• technique(s): western blot: 1:500-1:2,000
• UniProt accession no.: Q01105
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SET(6418)

Description

General description

SET (SET nuclear oncogene) is an oncoprotein. It is also termed as I2PP2A (protein phosphatase type 2A inhibitor II)/TAF-1β. It is located on human chromosome 9q34.11. SET belongs to the inhibitor of histone acetyltransferase (INHAT) complex, that blocks histone acetylation.

Immunogen

synthetic peptide corresponding to amino acids 56-70 of human SET

Application

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

SET (SET nuclear oncogene) oncoprotein participates in several aspects related to chromatin structure. It is considered as a histone chaperone, which is essential for chromatin transcription and a vital modulator of chromosome condensation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves