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RAB0558

Sigma-Aldrich

Mouse Esm1 / Endothelial Cell-specific Molecule 1 ELISA Kit

for serum, plasma and cell culture supernatants

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

mouse

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type serum
sample type plasma

assay range

inter-assay cv: <10%
intra-assay cv: <12%
sensitivity: 0.1 ng/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Esm1(71690)

General description

This ELISA antibody pair detects mouse Endothelial Cell-specific Molecule 1. Endothelial cell-specific molecule 1 (ESM1) is a secreted dermatan sulfate proteoglycan. This cysteine-rich protein is expressed in kidney glomeruli, specifically in renal epithelia and endothelial cells. Proangiogenic factors and cytokines modulate its activity.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Endothelial cell-specific molecule 1 (ESM1) may have a role in inflammation and angiogenesis. It has been linked to tumor growth. ESM1 stimulates vascular sprouting, growth, differentiation, migration and adhesion of cells.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)SDS
  • RABELADCELISA 1X Assay/Sample Diluent Buffer C (Item L)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1).
Cong R
Biochemical and Biophysical Research Communications (2006)
ESM1 mediates NGFR-induced invasion and metastasis in murine oral squamous cell carcinoma.
Chen C
Oncotarget (2016)
The non glycanated endocan polypeptide slows tumor growth by inducing stromal inflammatory reaction.
Yassine H
Oncotarget (2015)
Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability.
Rocha SF
Circulation Research (2014)
Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy.
Zheng X
PLoS ONE (2017)

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