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PZ0264

Sigma-Aldrich

CP-547632 hydrochloride

≥98% (HPLC)

Synonym(s):

3-[(4-Bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-Isothiazolecarboxamide hydrochloride, PF-01371182 hydrochloride

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25 MG
R 5 160,68

R 5 160,68

List PriceR 5 266,00
Please contact Customer Service for Availability
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25 MG
R 5 160,68

About This Item

Empirical Formula (Hill Notation):
C20H24BrF2N5O3S · HCl
CAS Number:
252003-71-7
Molecular Weight:
568.86
MDL number:
MFCD20268381
UNSPSC Code:
51111800
PubChem Substance ID:
329823800
NACRES:
NA.77

R 5 160,68

List PriceR 5 266,00
Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

NC(C1=C(NC(NCCCCN2CCCC2)=O)SN=C1OCC3=C(F)C=C(Br)C=C3F)=O.[H]Cl

InChI

1S/C20H24BrF2N5O3S.ClH/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28;/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30);1H

InChI key

NNPJZJJMQDXYGN-UHFFFAOYSA-N

Biochem/physiol Actions

CP-547632 hydrochloride is a well-tolerated, orally-bioavailable ATP-competitive kinase inhibitor. It is currently in clinical trials for the treatment of human malignancies.
CP-547632 is a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 = 11 and 9 nM, respectively). The compound CP-547632 inhibits VEGF and basic FGF-induced angiogenesis in animal models, and inhibits growth of xenograft tumors in mice.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000190117
0000190118
0000190117
0000190118
0000074354

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Jean S Beebe et al.
Cancer research, 63(21), 7301-7309 (2003-11-13)
Signaling through vascular endothelial growth factor (VEGF) receptors (VEGFRs) is a key pathway initiating endothelial cell proliferation and migration resulting in angiogenesis, a requirement for human tumor growth and metastasis. Abrogation of signaling through VEGFR by a variety of approaches

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