P8477
Picotamide
Synonym(s):
4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C21H20N4O3
CAS Number:
Molecular Weight:
376.41
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.83
Pricing and availability is not currently available.
Recommended Products
Assay
≥98%
Quality Level
form
powder
solubility
ethanol: 50 mg/mL, clear, colorless to light yellow
SMILES string
COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3
InChI
1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)
InChI key
KYWCWBXGRWWINE-UHFFFAOYSA-N
Gene Information
human ... TBXA2R(6915)
Biochem/physiol Actions
Eicosenoid receptor antagonist; a thromboxane A2 antagonist; antiplatelet agent.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Picotamide, an antithromboxane agent, inhibits the migration and proliferation of arterial myocytes.
S Ratti et al.
European journal of pharmacology, 355(1), 77-83 (1998-10-01)
Picotamide is an antiplatelet drug with a peculiar dual mechanism of action: it inhibits thromboxane A2 synthase and antagonizes the pharmacological responses mediated by thromboxane A2 receptor. We investigated the in vitro effect of picotamide on smooth muscle cell migration
R Vezza et al.
Thrombosis and haemostasis, 78(5), 1385-1391 (1998-01-04)
Picotamide is a dual thromboxane (Tx) A2 receptor antagonist/Tx synthase inhibitor although some observations suggest an anti-vasoconstrictor effect independent of TxA2 inhibition/antagonism. The aim of our study was to assess whether picotamide antagonises vascular contractions induced by different vasoactive substances
Carola Buccellati et al.
European journal of pharmacology, 443(1-3), 133-141 (2002-06-05)
We evaluated the capacity of anti-aggregating agents to influence thromboxane A(2) and prostacyclin formation, arachidonic acid-endoperoxide redirection, platelet aggregation and vessel tone, in isolated rabbit aorta incubated with homologous platelets. Picotamide (N,N'bis(3-pyridinylmethyl)-4-methoxy-isophthalamide), the only dual thromboxane A(2)-synthase inhibitor/receptor antagonist in
P Pancera et al.
Journal of internal medicine, 242(5), 373-376 (1998-01-04)
To assess the role of thromboxane A2 and of angiotensin II in patients with primary Raynaud's phenomenon. After an eight-day run-in period, the patients were enrolled in a single-blind, cross-over, study. Patients were examined at the Ambulatory for Microcirculatory Diseases
P L Malini et al.
Lancet (London, England), 350(9070), 15-18 (1997-07-05)
The increased prostaglandin synthesis that might follow stimulation of the arachidonic acid cascade by angiotensin-converting-enzyme inhibition (ACE-I) has been suggested to underlie the appearance of cough on ACE-I treatment. We investigated whether the prostanoid thromboxane was involved. Nine patients with
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
