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N3889

Sigma-Aldrich

Nitrazepam

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About This Item

Empirical Formula (Hill Notation):
C15H11N3O3
CAS Number:
146-22-5
Molecular Weight:
281.27
EC Number:
205-665-2
MDL number:
MFCD00058577
UNSPSC Code:
12352200
PubChem Substance ID:
24897666
NACRES:
NA.77

form

solid

drug control

USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

SMILES string

[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3)c2c1

InChI

1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)

InChI key

KJONHKAYOJNZEC-UHFFFAOYSA-N

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Biochem/physiol Actions

Hypnotic; ligand for the GABAA receptor benzodiazepine modulatory site.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Liu et al.
Journal of pharmaceutical sciences, 87(12), 1632-1638 (1999-04-03)
The purpose of this research was to investigate the influence of surfactants on the dissolution of benzodiazepines in interactive mixtures. The dissolution of ternary interactive mixtures consisting of micronized drugs (oxazepam, nitrazepam, and flunitrazepam) and micronized surfactants (sodium lauryl sulfate
N Inazu et al.
Biochemical pharmacology, 52(10), 1585-1591 (1996-11-22)
We investigated the effects of minor and major tranquilizers on ovarian and adrenal aldo-keto reductase activity towards five substrates in relation to ovulation in mature cycling rats. Nitrazepam (NZP) did not alter ovarian and adrenal weights or body weight, although
Shin Tokunaga et al.
Journal of pharmacological sciences, 103(2), 201-206 (2007-02-09)
The present study was undertaken to investigate the effects of some H(1)-antagonists on the sleep-wake cycle in sleep-disturbed rats in comparison with those of nitrazepam. Electrodes were chronically implanted into the frontal cortex and the dorsal neck muscle of rats
Mihalj Posa et al.
Talanta, 83(5), 1634-1642 (2011-01-18)
Linear dependence between temperature (t) and retention coefficient (k, reversed phase HPLC) of bile acids is obtained. Parameters (a, intercept and b, slope) of the linear function k=f(t) highly correlate with bile acids' structures. Investigated bile acids form linear congeneric
Ingebjørg Gustavsen et al.
Sleep medicine, 9(8), 818-822 (2008-01-30)
Despite the high prescription rate of benzodiazepine-like hypnotics (z-hypnotics), there is limited information on the road traffic accident risk associated with the use of these drugs. We wanted to investigate whether filling a prescription for zopiclone or zolpidem was associated
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