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N158

Sigma-Aldrich

Naftopidil hydrochloride hydrate

solid

Synonym(s):

4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate, KT-611

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25 MG
R 3 943,52

R 3 943,52

List PriceR 4 024,00
Please contact Customer Service for Availability
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25 MG
R 3 943,52

About This Item

Empirical Formula (Hill Notation):
C24H28N2O3 · xHCl · yH2O
CAS Number:
57149-07-2
Molecular Weight:
392.49 (anhydrous free base basis)
MDL number:
MFCD11046013
UNSPSC Code:
12352200
PubChem Substance ID:
24277790
NACRES:
NA.77

R 3 943,52

List PriceR 4 024,00
Please contact Customer Service for Availability

form

solid

Quality Level

200

color

white

solubility

methanol: >10 mg/mL
H2O: insoluble

SMILES string

O.Cl.COc1ccccc1N2CCN(CC2)CC(O)COc3cccc4ccccc34

InChI

1S/C24H28N2O3.ClH.H2O/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;;/h2-12,20,27H,13-18H2,1H3;1H;1H2

InChI key

INIDYCYXDNFBSV-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Biochem/physiol Actions

α1-Adrenoceptor antagonist; antihypertensive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000329583
0000329566
SLCM9335
SLCL0010
SLBQ0653V

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Hideyasu Tsumura et al.
International journal of radiation oncology, biology, physics, 81(4), e385-e392 (2011-06-15)
To compare the efficacy of three α(1A)/α(1D)-adrenoceptor (AR) antagonists--naftopidil, tamsulosin, and silodosin--that have differing affinities for the α(1)-AR subtypes in treating urinary morbidities in Japanese men with (125)I prostate implantation (PI) for prostate cancer. This single-institution prospective randomized controlled trial
S Yamada et al.
Life sciences, 50(2), 127-135 (1992-01-01)
Binding properties of naftopidil and alpha 1-adrenoceptor antagonists to alpha-adrenoceptors in prostates from benign prostatic hypertrophy (BPH) were characterized by radioreceptor assays using [3H]prazosin and [3H]rauwolscine. Specific binding of [3H]prazosin and [3H]rauwolscine in human prostatic membranes was saturable and of
Yasuo Tsuzaka et al.
International journal of urology : official journal of the Japanese Urological Association, 18(11), 792-795 (2011-09-16)
The aim of the present study was to compare the efficacy of the selective α(1D) -adrenoceptor antagonist naftopidil and the selective α(1A) -adrenoceptor antagonist silodosin (as an example) in the management of ureteral stones in Japanese male patients. A total
G Sponer et al.
Journal of cardiovascular pharmacology, 20(6), 1006-1013 (1992-12-01)
The interaction of naftopidil with adrenoceptors was studied in comparison to standard drugs. Naftopidil binds specifically to alpha 1-adrenoceptors. The Ki values are 58.3 nM for naftopidil, 0.43 nM for prazosin, and 197 nM for urapidil. The affinities of naftopidil
Xiawen Liu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 907, 140-145 (2012-10-03)
Two bioanalytical HPLC methods (chiral solid phases (CSPs) HPLC and pre-column derivatization HPLC) were developed and validated for the determination of naftopidil enantiomers in rat plasma. Analytes were extracted from biomaterials by liquid-liquid extraction. The pre-column derivatization HPLC method employed
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