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M6502

Sigma-Aldrich

6-Methylpurine

≥99%

Synonym(s):

MeP

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About This Item

Empirical Formula (Hill Notation):
C6H6N4
CAS Number:
Molecular Weight:
134.14
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51

biological source

synthetic (organic)

Assay

≥99%

form

powder

mp

237-238 °C (lit.)

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cc1ncnc2[nH]cnc12

InChI

1S/C6H6N4/c1-4-5-6(9-2-7-4)10-3-8-5/h2-3H,1H3,(H,7,8,9,10)

InChI key

SYMHUEFSSMBHJA-UHFFFAOYSA-N

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Application

6-Methylpurine (MeP) is a toxic adenine analog used as a bisubstrate inhibitor of enzymes that bind adenosyl moieties and which may become phosphorylated to levels that inhibit RNA and protein synthesis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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H Ohgaki et al.
Journal of cancer research and clinical oncology, 117(1), 13-18 (1991-01-01)
The formation of O6-methyldeoxyguanosine (O6-MedGuo) was determined by an immuno-slot-blot assay in DNA of various tissues of F344 rats exposed to N-methyl-N-nitrosourea (MNU) in the drinking water at 400 ppm for 2 weeks. Although the pyloric region of the glandular
Paromita Chakraborty et al.
Environmental pollution (Barking, Essex : 1987), 249, 1071-1080 (2019-05-31)
The Hooghly River (HR) estuary is the first deltaic off-shoot of the perennial and transboundary river, Ganga, India. HR receives industrial and domestic waste along with storm-water run-off from Kolkata city and the adjoining districts. Organic micropollutants (OMPs) have been
L J Lockett et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 3(11), 2075-2080 (1998-11-17)
Enzyme-prodrug therapy for the treatment of cancer is an experimental procedure that is under intensive investigation. However, the relative merits of the various systems for use under specific conditions are still being determined. We have compared the efficacy of cell
Hoonsik Yoom et al.
The Science of the total environment, 634, 677-686 (2018-04-12)
The reaction kinetics, products, and pathways of methylparaben (MeP) during water chlorination with and without bromide (Br-) were investigated to better understand the fate of parabens in chlorinated waters. During the chlorination of MeP-spiked waters without Br-, MeP was transformed
Theodoros Potouridis et al.
BMC chemistry, 13(1), 70-70 (2019-08-07)
Parabens and sorbic acid are commonly used as food preservatives due to their antimicrobial effect. However, their use in foods for infants and young children is not permitted in the European Union. Previous studies found these compounds in some gel-filled

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