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L6135

Sigma-Aldrich

Lectin from Arachis hypogaea (peanut)

biotin conjugate, lyophilized powder

Synonym(s):

PNA, Peanut agglutinin

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

conjugate

biotin conjugate

Quality Level

200

form

lyophilized powder

mol wt

120 kDa

composition

Protein, ≥80% Lowry

extent of labeling

~3 mol biotin per mol protein

technique(s)

blood typing: suitable
fractionation: suitable

solubility

water: 1.00-1.10 mg/mL, clear to slightly hazy, colorless

storage temp.

2-8°C

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General description

Peanut lectin (PNA) is a lectin or an agglutinin from the legume, Arachis hypogaea, found in peripheral venous blood in humans after ingestion of peanuts. PNA lectin is specific to the galactosyl (β-1,3) N-acetylgalactosamine.

Application

Lectin from Arachis hypogaea (peanut) has been used:
  • in enzyme-linked micro plate assay to detect β-D-galactose-N-acetylglucosamine
  • in Immunohistochemical double staining
  • Immunohistochemical double staining for the detection of germinal centers
  • in enzyme-linked microplate assayto detect β-D-galactose-N-acetylglucosamine

Biochem/physiol Actions

Lectin from Arachis hypogaea (peanut) functions as an antigenic determinant for Thomsen-Friedenreich antigen (TF) and as mitogen for colorectal cancer stimulation cell division in normal colonic epithelium. It is therefore used as tumor marker.
PNA does not agglutinate normal human erythrocytes, but strongly agglutinates neuraminidase treated erythrocytes. PNA has potent anti-T activity similar to the anti-T antibody in human sera. The lectin can be used to distinguish between human lymphocyte subsets.

Packaging

Package size based on protein content.

Physical form

Contains sodium citrate

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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In situ observation of germinal center cell apoptosis during a secondary immune response
Saitoh HA, et al.
Journal of Clinical and Experimental Hematopathology : JCEH, 46, 73-82 (2006)
Inhibition of influenza viral neuraminidase activity by collectins
Tecle T, et al.
Archives of Virology, 1731-1742 (2007)
Andreia Valença et al.
Experimental eye research, 202, 108292-108292 (2020-10-17)
Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in iron storage and detoxification, has
Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus--infected mice
GeurtsvanKessel CH, et al.
The Journal of Experimental Medicine, 206, 2339-2349 (2009)
Peanut lectin stimulates proliferation of colon cancer cells by interaction with glycosylated CD44v6 isoforms and consequential activation of c-Met and MAPK: functional implications for disease-associated glycosylation changes
Glycobiology, 16(7), 594-601 (2006)
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