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I1759

Sigma-Aldrich

Isosorbide dinitrate

powder

Synonym(s):

ISDN

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About This Item

Empirical Formula (Hill Notation):
C6H8N2O8
CAS Number:
87-33-2
Molecular Weight:
236.14
MDL number:
MFCD00868238
UNSPSC Code:
12352200
PubChem Substance ID:
24895946

form

powder

contains

~60% lactose

color

white

solubility

organic solvents: soluble (alcohol, acetone and ether)

SMILES string

[H][C@@]1([C@@]([H])(O[N+]([O-])=O)CO2)[C@@]2([H])[C@]([H])(O[N+]([O-])=O)CO1

InChI

1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2

InChI key

MOYKHGMNXAOIAT-UHFFFAOYSA-N

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Biochem/physiol Actions

Nitric oxide (NO) donor and nitrovasodilator. Induces stimulation of corpus mucin biosynthesis in vivo. Used to study the role of nitric oxide in the control of cell growth.

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Warning

Hazard Statements

H207,H302

Hazard Classifications

Acute Tox. 4 Oral - Desen. Expl. 3

Storage Class Code

4.1A - Other explosive hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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C Sciorati et al.
British journal of pharmacology, 122(4), 687-697 (1998-01-10)
1. The role of nitric oxide (NO) in the control of cell growth is controversial since both stimulation and (more often) inhibition have been demonstrated in various cell types. In order to reinvestigate the problem and identify the sites of
S Fujii et al.
The American journal of physiology, 274(5 Pt 1), G857-G862 (1998-06-05)
Recently, in vivo electron paramagnetic resonance (EPR) spectroscopy and imaging have been widely used to investigate free radical distribution and metabolism in tissues, organs, and whole body of small animals. Endogenous nitric oxide (NO) is an attractive target of this
Olivier Muller et al.
Circulation. Cardiovascular interventions, 5(6), 791-796 (2012-12-06)
To quantify the changes in arterial dimensions after the acute changes in pressure associated with percutaneous coronary intervention (PCI). Forty-eight patients with one angiographically moderate-to-severe stenosis were included in the study. The pressure proximal and distal to the stenosis and
Hydralazine and isosorbide dinitrate in heart failure: historical perspective, mechanisms, and future directions.
Robert T Cole et al.
Circulation, 123(21), 2414-2422 (2011-06-03)
W Schneider et al.
European heart journal, 9(2), 149-158 (1988-02-01)
Fourteen male patients with exertion-related angina pectoris and reproducible ST-segment depression on stress testing were each treated with isosorbide dinitrate (ISDN) 40 mg three times daily, verapamil 120 mg three times daily and placebo three times daily for two weeks
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