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HPA012883

Sigma-Aldrich

Anti-AGAP3 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-Arf-GAP, GTPase, ANK repeat and pH domain-containing protein 3, Anti-CRAG, Anti-CRAM-associated GTPase, Anti-Centaurin-γ-3, Anti-MR1-interacting protein, Anti-MRIP-1

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunohistochemistry: 1:20- 1:50

immunogen sequence

AKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAE

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... AGAP3(116988)

General description

AGAP3 (ADP ribosylation factor GTPase activating protein (Arf-GAP) with GTPase, ankyrin (ANK) repeat and pleckstrin homology domain (PH) domain-containing protein 3) is a guanosine triphosphatase (GTPase) which contains a nuclear localization signal (NLS) sequence. It is expressed in the brain and heart. It contains multiple domains involved in signaling like a GTPase-like domain, a PH domain and an ArfGAP domain. AGAP3 exists as a component of the N-methyl-D-aspartate receptor (NMDA) receptor complex.

Immunogen

Arf-GAP, GTPase, ANK repeat and pH domain-containing protein 3 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Biochem/physiol Actions

AGAP3 (ADP ribosylation factor GTPase activating protein (Arf-GAP) with GTPase, ankyrin (ANK) repeat and Pleckstrin homology domain (PH) domain-containing protein 3) has been shown to form nuclear inclusions in response to stress. It induces a ring-like structure of promyelocytic leukemia protein (PML) body. The degradation of polyglutamine (polyQ) at promyelocytic leukemia (PML) bodies is carried out by AGAP3 through the ubiquitin-proteasome pathway. The knockdown of AGAP3 blocks the nuclear translocation of polyQ and also enhances cell death mediated by polyQ. It has been suggested that AGAP3 is involved in the pathogenesis of polyglutamine diseases.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST86953

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yuko Oku et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(31), 12586-12598 (2013-08-02)
During NMDA receptor-mediated long-term potentiation (LTP), synapses are strengthened by trafficking AMPA receptors to the synapse through a calcium-dependent kinase cascade following activation of NMDA receptors. This process results in a long-lasting increase in synaptic strength that is thought to
Qingyu Qin et al.
The Journal of cell biology, 172(4), 497-504 (2006-02-08)
Polyglutamine diseases are inherited neurodegenerative diseases caused by the expanded polyglutamine proteins (polyQs). We have identified a novel guanosine triphosphatase (GTPase) named CRAG that contains a nuclear localization signal (NLS) sequence and forms nuclear inclusions in response to stress. After

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