E003876
BICINE
Synonym(s):
N,N-Bis(2-hydroxyethyl)glycine
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About This Item
Empirical Formula (Hill Notation):
C6H13NO4
CAS Number:
Molecular Weight:
163.17
Beilstein:
1769362
EC Number:
MDL number:
UNSPSC Code:
12161700
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useful pH range
7.6-9.0
pKa (25 °C)
8.3
SMILES string
OCCN(CCO)CC(O)=O
InChI
1S/C6H13NO4/c8-3-1-7(2-4-9)5-6(10)11/h8-9H,1-5H2,(H,10,11)
InChI key
FSVCELGFZIQNCK-UHFFFAOYSA-N
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Application
Recommended buffer for low temperature biochemical work. Used in the preparation of stable substrate solution for serum guanase determination. Spacer in plasma protein fractionation with Sephadex® by isotachophoresis.
Legal Information
Sephadex is a registered trademark of Cytiva
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Mohamed Taha
Annali di chimica, 94(12), 971-978 (2005-02-04)
The second stage dissociation constant pK2 of N,N-bis-(2-hydroxyethyl)glycine (bicine) has been determined in aqueous solution at different ionic strengths and different temperatures, using pH-metric technique. The thermodynamic quantities (deltaG(o), deltaH(o), and deltaS(o)) have been studied and discussed. Evaluation of the
Adverse effects of artificial buffers on contractile responses of arterial and venous smooth muscle.
B M Altura et al.
British journal of pharmacology, 69(2), 207-214 (1980-06-01)
1 In vitro studies were undertaken on rat aortic strips and portal vein segments in order to determine whether or not several commonly used artificial buffers, i.e., tris(hydroxymethyl) aminomethane (Tris), N-2-hydroxyethylpiperazine-N'-2-ethanesulphonic acid (HEPES), morpholine propanesulphonic acid (MOPS), N,N bis(2-hydroxyethyl) glycine
R Nakon et al.
Science (New York, N.Y.), 221(4612), 749-750 (1983-08-19)
Metal-ion affinity (formation) constants were determined for two "Good's" buffers, N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and N,N-bis(2-hydroxyethyl)glycine (bicine). The metal chelates formed undergo loss of an internal ligand (alcohol) proton (bicine) and undergo hydrolysis (bicine and TES) and dimerization reactions (TES). Bicine
Taufika Islam Williams et al.
Electrophoresis, 27(14), 2984-2995 (2006-05-24)
A novel, Bicine-based SDS-PAGE buffer system was developed for the analysis of membrane proteins. The method involves molecular weight-based separations of fully denatured and solubilized proteins in two dimensions. This doubled SDS-PAGE (dSDS-PAGE) approach produced a diagonal arrangement of protein
Raewyn M Town et al.
The journal of physical chemistry. A, 112(12), 2563-2571 (2008-03-04)
The impact of ligand protonation on the complexation kinetics of higher-order complexes is quantitatively described. The theory is formulated on the basis of the usual situation for metal complex formation in aqueous systems in which the exchange of water for
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