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C0358

Sigma-Aldrich

Z-Leu-Leu-Phe-CHO

≥95% (HPLC), solid

Synonym(s):

Cbz-Leu-Leu-Phe-CHO, Z-LLF-CHO

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About This Item

Empirical Formula (Hill Notation):
C29H39N3O5
CAS Number:
133429-58-0
Molecular Weight:
509.64
MDL number:
MFCD01862616
UNSPSC Code:
12352200
PubChem Substance ID:
329774778

Assay

≥95% (HPLC)

form

solid

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C=O

InChI

1S/C29H39N3O5/c1-20(2)15-25(27(34)30-24(18-33)17-22-11-7-5-8-12-22)31-28(35)26(16-21(3)4)32-29(36)37-19-23-13-9-6-10-14-23/h5-14,18,20-21,24-26H,15-17,19H2,1-4H3,(H,30,34)(H,31,35)(H,32,36)/t24-,25-,26-/m0/s1

InChI key

LIOIGKLWXFXXEG-GSDHBNRESA-N

Amino Acid Sequence

Z-Leu-Leu-Phe-al

General description

Manufactured for Sigma by Boston Biochem., Inc.

Biochem/physiol Actions

Cell permeable proteasome inhibitor acting on the chymotrypsin-like activity of the multicatalytic proteinase complex.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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S L Schauer et al.
Journal of immunology (Baltimore, Md. : 1950), 160(9), 4398-4405 (1998-05-09)
Recently, we demonstrated maintenance of nuclear factor (NF)-kappaB/Rel factors plays a major role in B cell survival. Treatment of WEHI 231 immature B cells with an Ab against the surface IgM protein (anti-IgM) induces apoptosis that can be rescued by

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