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B3806

Sigma-Aldrich

Bisindolylmaleimide VIII acetate salt

≥93% (H-NMR)

Synonym(s):

Ro 31-7549 acetate

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About This Item

Empirical Formula (Hill Notation):
C24H22N4O2 · C2H4O2
CAS Number:
138516-31-1
Molecular Weight:
458.51
MDL number:
MFCD00909467
UNSPSC Code:
12352200

Assay

≥93% (H-NMR)

solubility

DMSO: soluble
H2O: soluble
methanol: soluble

storage temp.

−20°C

SMILES string

CC(O)=O.Cn1cc(C2=C(C(=O)NC2=O)c3cn(CCCN)c4ccccc34)c5ccccc15

InChI

1S/C24H22N4O2.C2H4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20;1-2(3)4/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30);1H3,(H,3,4)

InChI key

VEOXVBTXROWDAH-UHFFFAOYSA-N

Biochem/physiol Actions

Bisindolylmaleimide VIII acetate is a selective inhibitor of protein kinase C (PKC). Bisindolylmaleimide VIII acetate enhances Fas- and TRAIL-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.

Caution

Photosensitive

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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