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B3056

Sigma-Aldrich

Bisindolylmaleimide II

≥97% (Mixture of 2 isomers)

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About This Item

Empirical Formula (Hill Notation):
C27H26N4O2
CAS Number:
137592-45-1
Molecular Weight:
438.52
MDL number:
MFCD00236430
UNSPSC Code:
12352111
PubChem Substance ID:
329773212
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

Assay

≥97% (Mixture of 2 isomers)

form

powder

solubility

DMSO: soluble
ethanol: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26

InChI

1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)

InChI key

LBFDERUQORUFIN-UHFFFAOYSA-N

Application

Bisindolylmaleimide II (BIS II) has been used:
  • as a protein kinase C (PKC) inhibitor to study its effects on cardiomyocyte phenotypes
  • as a PKC inhibitor along with methanandamide (mAEA) to study its effects on murine gastric vagal afferent (GVA) mechanosensitivity
  • as a PKC/protein kinase A (PKA) inhibitor to study its effects on bone-marrow cells

Biochem/physiol Actions

Bisindolylmaleimide II (BIS II) acts as a dual protein kinase A/C (PKA/C) inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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