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Key Documents

AV02052

Sigma-Aldrich

Anti-TNFRSF18 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-Tumor necrosis factor receptor superfamily, member 18

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

26 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_004186

UniProt accession no.

Q9Y5U5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TNFRSF18(8784)

General description

TNFRSF18 belongs to TNF receptor super family. It is a 228-amino acid type 1 transmembrane protein with a cysteine-rich extracellular domain.

Immunogen

Synthetic peptide directed towards the C terminal region of human TNFRSF18

Application

Anti-TNFRSF18 antibody produced in rabbit is suitable for western blotting at a concentration of 1 μg/ml. For immunohistochemistry of paraffin-embedded tissue sections, a concentration of 2-4 μg/ml is suitable.

Biochem/physiol Actions

TNFRSF18 regulates cell death mediated by T cell receptors. It has important role in inflammatory responses that are involved in autoimmune disorders such as collagen-induced arthritis, experimental autoimmune encephalomyelitis and autoimmune gastritis.

Sequence

Synthetic peptide located within the following region: LRSQCMWPRETQLLLEVPPSTEDARSCQFPEEERGERSAEEKGRLGDLWV

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC0359

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Theresa Placke et al.
Clinical & developmental immunology, 2010, 239083-239083 (2010-10-12)
The ability of the tumor necrosis factor receptor (TNFR) family member GITR to modulate immune responses has been the subject of multiple studies. Initially thought to be critically involved in governing functions of regulatory T cells, GITR and its ligand
T P Velavan et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 44(5), 418-420 (2011-03-30)
Parasites are accountable for driving diversity within immune gene families. We identified and investigated regulatory single nucleotide polymorphisms (SNPs) in the promoter regions of the tumor necrosis factor receptor superfamily member 18 (TNFRSF18) gene by direct sequencing in a group

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