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90771

Sigma-Aldrich

Poly(maleic anhydride-alt-1-tetradecene), 3-(dimethylamino)-1-propylamine derivative

BioReagent, for molecular biology

Synonym(s):

PMAL®-C12

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About This Item

Linear Formula:
(C23H44O3N2)n
CAS Number:
869857-14-7
UNSPSC Code:
12352200
NACRES:
NA.25

grade

Molecular Biology
for molecular biology

description

zwitterionic

product line

BioReagent

form

solid

λ

0.1 % in H2O

UV absorption

λ: 260 nm Amax: 0.400
λ: 280 nm Amax: 0.150

storage temp.

−20°C

Application

Use of "Amphipols" for delivering of membrane proteins to lipid bilayers, as activity support of membrane enzymes.

Analysis Note

enzyme traces DNases, RNases, and phosphatases not detectable

Legal Information

PMAL is a registered trademark of Affymetrix, Inc.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC2185
BCBZ3595
BCBJ5460V
BCBQ6755V
BCBJ5809V

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J K Nagy et al.
FEBS letters, 501(2-3), 115-120 (2001-07-27)
Data are presented which suggest that a class of amphiphilic polymers known as 'amphipols' may serve as a vehicle for delivering complex integral membrane proteins into membranes. The integral membrane protein diacylglycerol kinase (DAGK) was maintained in soluble form by
Bonnie M Gorzelle et al.
Journal of the American Chemical Society, 124(39), 11594-11595 (2002-09-26)
Amphipathic polymers ("amphipols") were introduced several years ago (Tribet, C.; Audebert, R.; Popot, J.-L. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 15047-15050) as an alternative method for solubilizing integral membrane proteins in stable, nativelike conformations. However, direct maintenance of full

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