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PHR1008

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Ascorbic Acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

L-Ascorbic acid, L-Threoascorbic acid, Antiscorbutic factor, Vitamin C

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2 G
R 1 843,38
10 G
R 9 812,74

R 1 843,38

List PriceR 1 881,00
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2 G
R 1 843,38
10 G
R 9 812,74

About This Item

Empirical Formula (Hill Notation):
C6H8O6
CAS Number:
50-81-7
Molecular Weight:
176.12
Beilstein:
84272
EC Number:
200-066-2
MDL number:
MFCD00064328
UNSPSC Code:
41116107
PubChem Substance ID:
329823039
E Number:
E300
NACRES:
NA.24

R 1 843,38

List PriceR 1 881,00
Please contact Customer Service for Availability
Request a Bulk Order

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 461
traceable to Ph. Eur. A1300000
traceable to USP 1043003

API family

ascorbic acid

form

solid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

190-194 °C (dec.)

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Ascorbic acid is a powerful antioxidant and is widely used in pharmaceutical formulations.[1][2] It has proven to have a beneficial effect on age-related diseases such as cancer, atherosclerosis, ocular, neurodegenerative diseases, etc. It is mainly involved in the formation and maintenance of collagen.[3] The prolonged deficiency of ascorbic acid in diet may result in scurvy.[2]

Application

Ascorbic Acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using hydrophilic interaction chromatography.[1]

Biochem/physiol Actions

Ascorbic Acid, also known as Vitamin C, is a six-carbon lactone produced by plants and some animal species but not by humans and other primates. Ascorbic acid functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Ascorbic acid also functions as a powerful antioxidant, particularly in regards to reactive oxygen species.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2886 in the slot below. This is an example certificate only and may not be the lot that you receive.

analytical column

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Description
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Description
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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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L-ascorbic acid determination in pharmaceutical formulations using a biosensor based on carbon paste modified with crude extract of Zucchini (Cucurbita pepo)
Fatibello-Filho and Vieira CI
Journal of the Brazilian Chemical Society, 11(4), 412-418 (2000)
Method development and validation for optimised separation of salicylic, acetyl salicylic and ascorbic acid in pharmaceutical formulations by hydrophilic interaction chromatography and response surface methodology
Hatambeygi N, et al.
Journal of Chromatography A, 1218(35), 5995-6003 (2011)
Simultaneous differential pulse voltammetric determination of ascorbic acid and caffeine in pharmaceutical formulations using a boron?doped diamond electrode
Lourencao CB, et al.
Electroanalysis, 22(15), 1717-1723 (2010)
Noriko Umegaki-Arao et al.
Science translational medicine, 6(264), 264ra164-264ra164 (2014-11-28)
Revertant mosaicism is a naturally occurring phenomenon involving spontaneous correction of a pathogenic gene mutation in a somatic cell. It has been observed in several genetic diseases, including epidermolysis bullosa (EB), a group of inherited skin disorders characterized by blistering
Stefanie B Murer et al.
The Journal of nutrition, 144(2), 193-201 (2013-12-20)
Oxidative stress and low-grade systemic inflammation may contribute to the pathogenesis of obesity-induced comorbidities, including nonalcoholic fatty liver disease. Increasing intake of dietary antioxidants might be beneficial, but there are few data in obese children. To examine the effect of
View All Related Papers

Articles

Determination of Ascorbic Acid and Dehydroascorbic Acid in Different Food Products and Supplements - A Simple HPTLC Based Approach

Simultaneous analysis of ascorbic acid and dehydroascorbic acid in various food samples by High Performance Thin Layer Chromatography (HPTLC).

Separation of Organic Acids with 100% aqueous mobile phase using an Ascentis® Express AQ-C18 HPLC Column

A new RP-HPLC method is proposed for the determination of organic acids in 100% aqueous mobile phase using an Ascentis® Express AQ-C18 column

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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