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34093

Supelco

Closantel

PESTANAL®, analytical standard

Synonym(s):

5′-Chloro-4′-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2′-methylsalicylanilide, N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide

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About This Item

Empirical Formula (Hill Notation):
C22H14Cl2I2N2O2
CAS Number:
57808-65-8
Molecular Weight:
663.07
EC Number:
260-967-1
MDL number:
MFCD00661151
UNSPSC Code:
41116107
PubChem Substance ID:
329754809
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

agriculture
environmental

format

neat

storage temp.

2-8°C

SMILES string

Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c3cc(I)cc(I)c3O

InChI

1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)

InChI key

JMPFSEBWVLAJKM-UHFFFAOYSA-N

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General description

Closantel belongs to the salicylanilide class of anthelmintics, that can extensively bind to the plasma albumin. It can be effectively used against, a vast range of blood feeding internal parasites.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ5430
BCBZ7571
BCBT3303
SZBC320XV
SZBA292XV

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K M Cooper et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(8), 1263-1271 (2012-05-29)
The ProSafeBeef project studied the prevalence of residues of anthelmintic drugs used to control parasitic worms and fluke in beef cattle in Ireland. Injured (casualty) cattle may enter the human food chain under certain conditions, verified by an attending veterinarian
Haemonchus contortus: the uptake and metabolism of closantel
Rothwell J and Sangster N
International Journal For Parasitology, 27, 313-319 (1997)
L Cromie et al.
Journal of veterinary pharmacology and therapeutics, 29(3), 205-211 (2006-05-04)
Two studies are described on the pharmacokinetics of a combination anthelmintic consisting of ivermectin and closantel for use in cattle. In the first, the pharmacokinetics of both active drugs in the combination were compared with the formulation with either ivermectin
The effect of a parenteral ivermectin/closantel injection on the growth and reproductive development of early immature Fasciola hepatica in cattle
Hanna.B.E.R, et al.
Veterinary Parasitology, 142, 78-90 (2006)
R E B Hanna et al.
Veterinary parasitology, 142(1-2), 78-90 (2006-08-12)
Sixteen calves approximately 6 months old were each infected with 500 metacercariae of Fasciola hepatica. Thirty-two days later they were weighed and divided into two groups, and on day 35 all calves in one of the groups were injected subcutaneously
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