12070
Benzamide
purum, ≥98.0% (HPLC)
Synonym(s):
Benzoic acid amide
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About This Item
Linear Formula:
C6H5CONH2
CAS Number:
Molecular Weight:
121.14
Beilstein:
385876
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
Recommended Products
grade
purum
Assay
≥98.0% (HPLC)
mp
125-128 °C (lit.)
125-128 °C
solubility
methanol: soluble 1 g/10 mL, clear, colorless to faintly yellow
SMILES string
NC(=O)c1ccccc1
InChI
1S/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)
InChI key
KXDAEFPNCMNJSK-UHFFFAOYSA-N
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Application
Benzamide was used to study the effect of inhibitors of endonuclease and poly(ADP ribose) polymerase on anti-Fas monoclonal antibody treated Jurkat cells.
Biochem/physiol Actions
Benzamide is a specific inhibitor of poly(ADP-ribose)polymerase. It prevents glutamate- and methamphetamine-induced neurotoxicity in vitro in C57B1/6N mouse.
Inhibits poly(ADP-ribose) polymerase (PARP).
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Product No.
Description
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Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Muta. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
356.0 °F - closed cup
Flash Point(C)
180 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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I Yamadori et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 46(1), 85-90 (1997-12-24)
We compared two methods to stain apoptotic cells, one using terminal deoxynucleotidyl transferase (TDT), the other DNA polymerase I, using leukemia cell lines treated with anti-Fas monoclonal antibody (MAb). Both TDT and polymerase I strongly reacted with fragmented nuclei of
E Kun et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(23), 7219-7223 (1983-12-01)
Human fibroblasts were subjected to nutritionally induced G1 block, followed by release and subsequent entry into S phase, and exposed to nontoxic concentrations of carcinogens in early S phase. Cell transformation occurred as determined by early morphologic cell alterations, anchorage-independent
C Cosi et al.
Brain research, 735(2), 343-348 (1996-10-07)
Previous studies have indicated that the activation of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA plasticity-related phenomena, is an early event occurring in glutamate-induced neurotoxicity in vitro, and that inhibitors of PARP, including benzamide, are protective against both glutamate-
James M Wright et al.
The Cochrane database of systematic reviews, 4, CD001841-CD001841 (2018-04-19)
This is the first update of a review published in 2009. Sustained moderate to severe elevations in resting blood pressure leads to a critically important clinical question: What class of drug to use first-line? This review attempted to answer that
A P de Jong et al.
Journal of chromatography, 419, 233-242 (1987-08-07)
A universal rapid, sensitive and selective high-performance liquid chromatographic method with UV detection at 230 nm has been developed for the determination of benzamide drugs in human plasma and urine. Sample pretreatment is carried out using solid-phase extraction columns, resulting
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