699851P

3A-MPLA

Avanti Research^™ - A Croda Brand 699851P, powder

• Synonym(s): Monophosphoryl Tri-acyl Lipid A (Synthetic)
• Empirical Formula (Hill Notation): C₅₄H₁₀₆N₃O₁₇P
• CAS Number: 1699735-80-2
• Molecular Weight: 1100.40
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (HPLC)
• form: powder
• packaging: pkg of 1 × 1 mg (699851P-1mg); pkg of 1 × 5 mg (699851P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 699851P
• application(s): vaccine development
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1O)O[C@H](O)[C@@H]2NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2O.[NH4+]
• InChI: 1S/C54H103N2O17P.H3N/c1-4-7-10-13-16-19-20-23-26-29-32-35-46(61)70-41(34-31-28-25-22-18-15-12-9-6-3)37-45(60)56-48-51(64)52(73-74(66,67)68)42(38-57)72-54(48)69-39-43-49(62)50(63)47(53(65)71-43)55-44(59)36-40(58)33-30-27-24-21-17-14-11-8-5-2;/h40-43,47-54,
• InChI key: WBMOMCHVNLUEBA-MWYCKLIASA-N

Description

General description

Monophosphoryl lipid A (MPLA) is an analog of the lipid A moiety.[1] It is regarded as a detoxified derivative of the lipopolysaccharide (LPS).[2]

Biochem/physiol Actions

Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications.[3] It induces tumor necrosis factor and interleukin (IL)-1β, however not as efficient as lipopolysaccharide (LPS). MPLA improves immune response during bacterial sepsis infection.

Packaging

2 mL Amber Glass Crimp Cap Vial (699851P-1mg)

2 mL Amber Glass Crimp Cap Vial (699851P-5mg)

Other Notes

For R&D use only. Not for drug, household, or other uses.

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): No data available
• Flash Point(C): No data available