We previously reported a novel method for the precise prediction of tablet properties (e.g., tensile strength (TS)) using a small number of experimental data. The key technique of this method is to compensate for the lack of experimental data by
Chemical & pharmaceutical bulletin, 47(3), 417-420 (1999-04-23)
Solid dispersions of carbamazepine or ethenzamide were prepared by melting and rapid cooling with liquid nitrogen using lactose as a carrier. The physical characteristics of these solid dispersions were investigated by powder X-ray diffraction, differential scanning calorimetry, and dissolution rate
Drug development and industrial pharmacy, 24(3), 225-233 (1999-01-07)
In this study, acetaminophen, ascorbic acid, and ethenzamide were selected as model drugs for tableting granules. Agitation and fluidized-bed granulation were carried out at three drug contents of 30, 50, and 70%. Compared with agitation granulation, granules made by fluidized-bed
Journal of magnetic resonance (San Diego, Calif. : 1997), 202(2), 135-139 (2009-11-11)
An efficient method to separate the (13)C NMR spectra of solid mixtures is introduced. The (1)H longitudinal (T(1)) relaxation time is used to separate the overlapping (13)C chemical shift spectra of solid mixtures via an inverse Laplace transform (ILT) of
International journal of pharmaceutics, 441(1-2), 135-145 (2012-12-19)
The objective of this study was to evaluate the high shear granulation process using near-infrared (NIR) chemical imaging technique and to make the findings available for pharmaceutical development. We prepared granules and tablets made under appropriate- and over-granulation conditions with
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