Skip to Content
Merck
All Photos(2)

Documents

540838

Sigma-Aldrich

4-Piperidine butyric acid hydrochloride

97%

Synonym(s):

4-(Piperidin-4-yl)butanoic acid hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C9H18ClNO2
CAS Number:
84512-08-3
Molecular Weight:
207.70
MDL number:
MFCD02684340
UNSPSC Code:
12352100
PubChem Substance ID:
24878498
NACRES:
NA.22

Assay

97%

mp

113-117 °C (lit.)

SMILES string

Cl[H].OC(=O)CCCC1CCNCC1

InChI

1S/C9H17NO2.ClH/c11-9(12)3-1-2-8-4-6-10-7-5-8;/h8,10H,1-7H2,(H,11,12);1H

InChI key

UTPNREIRALGKPW-UHFFFAOYSA-N

Related Categories

General description

4-Piperidine butyric acid hydrochloride participates in the synthesis of FK866 [(E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide], an inhibitor of NAD biosynthesis.

Application

Reactant for:
Modification of 3-amidinophenylalanine-derived matriptase inhibitors
Reactions between Weinreb amides and 2-magnesiated oxazoles

Reactant for synthesis of:
NAmPRTase inhibitors
FK866 analogs for NAD salvage inhibition

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

210.2 °F - closed cup

Flash Point(C)

99 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Ubaldina Galli et al.
ChemMedChem, 3(5), 771-779 (2008-02-06)
One of the great challenges of medicinal chemistry is to create novel, effective, chemotherapeutic agents that show specificity for cancer cells combined with low systemic toxicity. A novel idea is to target the enzymes of the NAD biosynthesis and recycling
Hyun You et al.
European journal of medicinal chemistry, 46(4), 1153-1164 (2011-02-19)
NAmPRTase (PBEF/Visfatin) plays a pivotal role in the salvage pathway of NAD(+) biosynthesis. NAmPRTase has been an attractive target for anti-cancer agents that induce apoptosis of tumor cells via a declining plasma NAD(+) level. In this report, a series of
Characterization of NAD uptake in mammalian cells.
Billington RA, et al.
The Journal of Biological Chemistry, 283(10), 6367-6374 (2008)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service