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531995

Sigma-Aldrich

2-Chloro-N-benzylacetamide

97%

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About This Item

Linear Formula:
C6H5CH2NHCOCH2Cl
CAS Number:
2564-06-9
Molecular Weight:
183.63
MDL number:
MFCD00084929
UNSPSC Code:
12352100
PubChem Substance ID:
24877852
NACRES:
NA.22

Assay

97%

mp

93-96 °C (lit.)

functional group

amide
chloro
phenyl

SMILES string

ClCC(=O)NCc1ccccc1

InChI

1S/C9H10ClNO/c10-6-9(12)11-7-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,12)

InChI key

SRAXAXHQMCQHSH-UHFFFAOYSA-N

General description

2-Chloro-N-benzylacetamide can be prepared by reacting benzylamine and chloroacetylchloride.

Application

2-Chloro-N-benzylacetamide may be used in the preparation of:
  • 2-[4-(Aryl substituted) piperazin-1-yl]-N-benzylacetamides by reacting with corresponding arylpiperazines.
  • N-Methylacetamide and N-benzylacetamide by reacting with di-tert-butyl 1,4,7-triazacyclononane-1,4-diacetate.
  • bis[N-Benzyl-2-(quinolin-8-yl­oxy)acetamide] monohydrate by reacting with 8-hydroxyquinoline.
  • N-Benzyl-2-(1H-imidazol-1-yl)acetamide by reacting with imidazole.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
02908KE
10626EI

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Chiral Variation of a Hybrid Bis (carbene-amido) Ligand System.
Jean-Baptiste dit Dominique F, et al.
Organometallics, 29(13), 2868-2873 (2010)
Synthesis, computational studies and preliminary pharmacological evaluation of 2-[4-(aryl substituted) piperazin-1-yl]-N-benzylacetamides as potential antipsychotics.
Kumar S, et al.
Arabian Journal of Chemistry (2012)
Bis [N-benzyl-2-(quinolin-8-yloxy) acetamide] monohydrate.
Wang MS, et al.
Acta Crystallographica Section E, Structure Reports Online, 67(7), o1558-o1558 (2011)
Formation and Characterization of Gallium (III) Complexes with Monoamide Derivatives of 1,4,7-Triazacyclononane-1,4,7-triacetic Acid: A Study of the Dependency of Structure on Reaction pH.
Shetty D, et al.
European Journal of Inorganic Chemistry, 2010(34), 5432-5438 (2010)

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