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437352

Sigma-Aldrich

4-(1-Pyrrolidinyl)piperidine

95%

Synonym(s):

1-(Piperidin-4-yl)pyrrolidine

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About This Item

Empirical Formula (Hill Notation):
C9H18N2
CAS Number:
5004-07-9
Molecular Weight:
154.25
EC Number:
225-676-6
MDL number:
MFCD00038011
UNSPSC Code:
12352100
PubChem Substance ID:
24867366
NACRES:
NA.22
Pricing and availability is not currently available.

Assay

95%

form

solid

mp

53-56 °C (lit.)

SMILES string

C1CCN(C1)C2CCNCC2

InChI

1S/C9H18N2/c1-2-8-11(7-1)9-3-5-10-6-4-9/h9-10H,1-8H2

InChI key

STWODXDTKGTVCJ-UHFFFAOYSA-N

General description

4-(1-Pyrrolidinyl)piperidine (4-pypp) has been reported to form Hofmann type complexes [M(4-pypp)2Ni(CN)4] (M=Ni or Co) and their FT-IR and Raman spectra have been studied.[1] FT-IR, Raman spectra and the vibrational spectra of 4-pypp have been recorded between 4000 and 400cm-1.[2]

Application

4-(1-Pyrrolidinyl)piperidine was employed for the synthesis of the following analogs:[3]
  • 4-pyrrolidin-1´-yl-1-[2-(2″-nitro-phenyl)-2-oxo-ethyl]-piperidinium bromide
  • 4-pyrrolidin-1´-yl-1-[2-(3″-nitro-phenyl)-2-oxo-ethyl]-piperidinium bromide
  • 4-pyrrolidin-1´-yl-1-[2-(2″,4″-dimethoxy-phenyl)-2-oxo-ethyl]-piperidinium bromide
  • 4-pyrrolidin-1´-yl-1-[2-(3″,4″-dihydroxy-phenyl)-2-oxo-ethyl]-piperidinium bromide
Reactant for synthesis of:
Small molecule ligands of methyl-lysine binding proteins
Small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells
Selective Polo-like kinase 1 inhibitors
Molecules with effects on plasma glucose levels
Vasopressin1b receptor antagonists
IKKβ inhibitors

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
18097JJV
26697JJ
18097JJ
14030KH
01411DH

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Nousheen Mushtaq et al.
Pakistan journal of pharmaceutical sciences, 23(2), 220-223 (2010-04-07)
In the present study some compounds of 4-(1-Pyrrolidinyl) Piperidine (I) have been synthesized. Structures of compounds were confirmed by using HNMR, IR, Mass and UV spectrophotometer techniques. All the derivatives (II, III, IV and V) and the parent compound (I)
Cemal Parlak
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 99, 12-17 (2012-10-09)
Some new Hofmann type complexes with chemical formula of M(4 pypp)(2)Ni(CN)(4) (where 4 py pp=4-(1-pyrrolidinyl)piperidine and MNi or Co) were prepared and their FT-IR and Raman spectra were reported in the region of 4000-200 cm(-1) and 4000-100 cm(-1), respectively. The
Theoretical and experimental vibrational spectroscopic study of 4-(1-Pyrrolidinyl) piperidine.
Parlak C.
Journal of Molecular Structure, 966(1), 1-7 (2010)

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