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SML1920

ML364

≥98% (HPLC)

Synonym(s):

2-(4-Methylphenylsulfonamido)-N-(4-phenylthiazol-2-yl)-4-(trifluoromethyl)benzamide, 2-[[(4-Methylphenyl)sulfonyl]amino]-N-(4-phenyl-2-thiazolyl)-4-(trifluoromethyl)-benzamide

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About This Item

Empirical Formula (Hill Notation):
C24H18F3N3O3S2
CAS Number:
1991986-30-1
Molecular Weight:
517.54
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cc(c(cc1)C(=O)Nc3[s]cc(n3)c4ccccc4)N[S](=O)(=O)c2ccc(cc2)C

InChI key

QZUGMNXETPARLI-UHFFFAOYSA-N

Biochem/physiol Actions

ML364 is a potent and specific inhibitor of the deubiquitinase USP2 that induces cellular Cyclin D1 degradation in HCT116 colorectal cancer cells, followed by cell cycle arrest and apoptosis. Also, ML364 inhibits homologous recombination (HR)-mediated DNA repair.
Potent and specific inhibitor of the deubiquitinase USP2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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