SML0499

NCTT-956

≥97% (NMR)

• Synonym(s): N-[(8-Hydroxy-5-nitro-7-quinolinyl)-2-thienylmethyl]-propanamide
• Empirical Formula (Hill Notation): C₁₇H₁₅N₃O₄S
• CAS Number: 438575-88-3
• Molecular Weight: 357.38
• NACRES: NA.77
• PubChem Substance ID: 329825448
• UNSPSC Code: 51111800
• MDL number: MFCD02228855
• Assay: ≥97% (NMR)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥97% (NMR)
• form: powder
• color: light orange to dark orange
• solubility: DMSO: 5 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: CCC(=O)NC(c1cccs1)c2cc([N+]([O-])=O)c3cccnc3c2O
• InChI: 1S/C17H15N3O4S/c1-2-14(21)19-15(13-6-4-8-25-13)11-9-12(20(23)24)10-5-3-7-18-16(10)17(11)22/h3-9,15,22H,2H2,1H3,(H,19,21)
• InChI key: DEXNORPUTBBNSC-UHFFFAOYSA-N

Description

Biochem/physiol Actions

NCTT-956 is a potent, specific 12-LO inhibitor.

NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity, with an IC₅₀ of 800 nM, no activity against 5-LO and greater than 25-fold selectivity over 15-LO. Specific inhibition of 12-LO by NCTT-956 in platelets blocks PKC activation, aggregation, granule secretion and αIIbB3 activation.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319
• pcodes: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable