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D6140
Demeclocycline hydrochloride
powder or crystals, suitable for cell culture
Synonym(s):
7-Chloro-6-demethyltetracycline hydrochloride, Demethylchlorotetracycline hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C21H21ClN2O8 · HCl
CAS Number:
Molecular Weight:
501.31
NACRES:
NA.75
PubChem Substance ID:
UNSPSC Code:
12352207
EC Number:
200-592-2
MDL number:
Beilstein/REAXYS Number:
3849198
Pricing and availability is not currently available.
Product Name
Demeclocycline hydrochloride, powder or crystals
assay
89.5-102.0% anhydrous basis
Quality Level
form
powder or crystals
technique(s)
cell culture | mammalian: suitable
solubility
soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
protein synthesis | interferes
storage temp.
−20°C
SMILES string
Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O
InChI
1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1
InChI key
GVSJQNRGSCOSNJ-KBHRXELFSA-N
General description
Chemical structure: tetracycline
Biochem/physiol Actions
Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.
Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.
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This Item | |||
|---|---|---|---|
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| technique(s) cell culture | mammalian: suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - |
| mode of action protein synthesis | interferes | mode of action - | mode of action - | mode of action - |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level - |
| form powder or crystals | form - | form - | form - |
| assay 89.5-102.0% anhydrous basis | assay - | assay - | assay - |
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Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Sierra H Root et al.
Stem cells (Dayton, Ohio), 38(6), 769-781 (2020-02-14)
Bone remodeling and regeneration are dependent on resident stem/progenitor cells with the ability to replenish mature osteoblasts and repair the skeleton. Using lineage tracing approaches, we identified a population of Dmp1+ cells that reside within cortical bone and are distinct
B Athanassiadis et al.
Australian dental journal, 54(2), 141-146 (2009-05-29)
The aim of this study was to determine the in vitro antimicrobial activities of various endodontic medicaments and their bases against selected organisms using an agar diffusion assay. An agar well diffusion assay was used to test the antimicrobial action
P Abbott et al.
Australian dental journal, 54(4), 306-315 (2010-04-27)
The aims of this study were to assess symptoms and signs caused by cracks in teeth and to assess a conservative management protocol. The symptoms and signs of 100 consecutive teeth that had reversible pulpitis associated with cracks were compared
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D6140-1G | 04061833587317 |
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What is the Department of Transportation shipping information for this product?
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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What is the solubility of Product D6140, Demeclocycline hydrochloride?
1 answer-
Product D6140, Demeclocycline hydrochloride, has been found to be soluble in water at 20mg/ml, with heat as needed. This will yield a clear yellow to very dark green-yellow solution.
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