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CITCO

Name: CITCO
Brand: SIGMA

≥98% (HPLC), androstane receptor agonist, solid

Synonym(s):

6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₂N₃OCl₃S

CAS Number:

338404-52-7

Molecular Weight:

436.74

UNSPSC Code:

12352203

PubChem Substance ID:

24724448

NACRES:

NA.77

MDL number:

MFCD00139608

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

desiccated

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Properties

Product Name

CITCO, ≥98% (HPLC), solid

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

solubility

DMSO: soluble 28 mg/mL, H₂O: insoluble

storage temp.

−20°C

SMILES string

Clc1ccc(cc1)-c2nc3sccn3c2\C=N\OCc4ccc(Cl)c(Cl)c4

InChI

1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+

InChI key

ZQWBOKJVVYNKTL-AUEPDCJTSA-N

Description

General description

CITCO is an imidazothiazole derivative. It stimulates human constitutive androstane receptor (CAR) nuclear translocation.

Application

CITCO has been used for the activation of mouse constitutive androstane receptor (CAR) and human CAR.

Biochem/physiol Actions

CITCO is a constitutive androstane receptor (CAR) agonist; nuclear receptor NR113 agonist.

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This Item	385920	565840	SML2410
Sigma-Aldrich C6240 CITCO	Sigma-Aldrich 385920 HSP90 Inhibitor, CCT018159	Sigma-Aldrich 565840 SHIP2 Inhibitor, AS1938909	Sigma-Aldrich SML2410 ABC99
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form solid	form powder
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level -
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: soluble 28 mg/mL, H₂O: insoluble	solubility water: 1.7 mg/mL, DMSO: 35 mg/mL, ethanol: 35 mg/mL	solubility DMSO: 50 mg/mL	solubility DMSO: 2 mg/mL, clear
storage condition desiccated	storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light	storage condition -

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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