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Merck

91C

Leukocyte Naphthol AS-D Chloroacetate (Specific Esterase) Kit

Synonym(s):

Leder Stain

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About This Item

NACRES:
NA.47
UNSPSC Code:
12352106

Key Documents

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description

Kit formulated with all liquid reagents

shelf life

Expiry date on the label.

IVD

for in vitro diagnostic use

dilution

(for histology)

application(s)

hematology
histology

shipped in

wet ice

storage temp.

2-8°C

Quality Level

500

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Application

Esterases are ubiquitous in nature and encompass a series of different enzymes acting upon select substrates. With the 91C kit, Naphthol AS-D Chloroacetate is enzymatically hydrolyzed by "specific esterase, " liberating a free naphthol compound. This then couples with a diazonium compound, forming highly colored deposits at sites of enzyme activity. This enzyme is usually considered specific for cells of granulocytic lineage. May be used to detect neutrophils in peripheral blood, bone marrow or tissue sections which have been paraffin embedded.

Kit Components Also Available Separately

Product No.
Description
SDS
  • 915Citrate Solution, pH 3.6±0.1 (25 °C), 27 mM 50 mLSDS
  • 912Fast Red Violet LB Base Solution 10 mLSDS
  • 911Naphthol AS-D Chloroacetate Solution 10 mLSDS
  • 911Naphthol AS-D Chloroacetate Solution 50 mLSDS

signalword

Danger

target_organs

Kidney, Respiratory system

supp_hazards

EUH019

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 Oral - STOT SE 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000524712
0000505032
0000524712
0000505032
0000505029

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Ganesan Ramesh et al.
Kidney international, 65(2), 490-499 (2004-01-14)
Salicylate was recently shown to provide protection against cisplatin nephrotoxicity in rats. We have demonstrated that enhanced tumor necrosis factor-alpha (TNF-alpha) production mediates, in part, cisplatin nephrotoxicity. The purpose of this study was to determine if the protective effects of
C Herzog et al.
Kidney international, 71(10), 1009-1018 (2007-03-23)
Meprins are zinc-dependent metalloproteinases that are highly expressed in the brush-border membranes of both the kidney and the intestines. Meprins are capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. In
Paramahamsa Maturu et al.
Translational oncology, 7(4), 484-492 (2014-06-28)
The role of inflammation in cancer has been reported in various adult malignant neoplasms. By contrast, its role in pediatric tumors has not been as well studied. In this study, we have identified and characterized the infiltration of various inflammatory
Ralf A Linker et al.
Journal of immunology (Baltimore, Md. : 1950), 180(4), 2204-2213 (2008-02-06)
The neurotrophic cytokines ciliary neurotrophic factor and leukemia inhibitory factor (LIF) play a key role in neuronal and oligodendrocyte survival and as protective factors in neuroinflammation. To further elucidate the potential of endogenous LIF in modulating neuroinflammation, we studied myelin
Vittoria Esposito et al.
American journal of physiology. Renal physiology, 304(4), F440-F450 (2012-12-14)
C/EBP homologous protein (CHOP) is an important mediator of endoplasmic reticulum (ER) stress-induced cell and organ injury. Here we show that lipopolysaccharide (LPS)-induced acute kidney injury (AKI) is associated with ER stress and elevated CHOP. We postulated that CHOP(-/-) mice
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