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Sigma-Aldrich

Cymarin

≥96% (HPLC)

Synonym(s):

K-Strophanthidin-D-cymaroside, K-Strophanthin-α

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About This Item

Empirical Formula (Hill Notation):
C30H44O9
CAS Number:
508-77-0
Molecular Weight:
548.66
Beilstein:
101370
EC Number:
208-087-9
MDL number:
MFCD00003669
UNSPSC Code:
12352211
PubChem Substance ID:
57648403
NACRES:
NA.77

Assay

≥96% (HPLC)

SMILES string

CO[C@H]1C[C@@H](O[C@H](C)[C@H]1O)O[C@H]2CC[C@]3(C=O)C4CC[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6

InChI

1S/C30H44O9/c1-17-26(33)23(36-3)13-25(38-17)39-19-4-9-28(16-31)21-5-8-27(2)20(18-12-24(32)37-15-18)7-11-30(27,35)22(21)6-10-29(28,34)14-19/h12,16-17,19-23,25-26,33-35H,4-11,13-15H2,1-3H3/t17-,19+,20-,21+,22-,23+,25+,26-,27-,28+,29+,30+/m1/s1

InChI key

XQCGNURMLWFQJR-ZNDDOCHDSA-N

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Application

Cymarin was used to study the effect of cardiac glycosides on vascular smooth muscles and ion transport.

Biochem/physiol Actions

Cymarin is a cardiac glycoside and is classified as cardiotonic steroid. It inhibits ion transport by decreasing the activity of (Na-K)-ATPase.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301 + H331,H373

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - STOT RE 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Z B Skorzova et al.
Sudebno-meditsinskaia ekspertiza, 32(2), 35-36 (1989-04-01)
Private technique of extraction isolation and purification, chromatographic detection and photometric determination of zimarin in urine is suggested. Detection limit is 0.01 mg, determination limit is 0.1 mg of glycoside in 100 ml of urine. Method makes it possible to
E V Lopatina et al.
Bulletin of experimental biology and medicine, 146(6), 744-746 (2009-06-11)
We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal tissue explants. Ouabain (10(-13)M)
Young-Jae You et al.
Phytotherapy research : PTR, 17(5), 568-570 (2003-05-16)
Antiangiogenic activity-guided fractionation and isolation carried out on the methanol extract of Adonis amurensis led to the identification of three compounds, namely cymarin, cymarol, and cymarilic acid. Amongst the three compounds, cymarilic acid was isolated from this plant for the
Increased in vivo synthesis of retinal Na pump isoforms after pre-treatment with citrate buffer.
S C Specht et al.
Progress in clinical and biological research, 268B, 143-147 (1988-01-01)
[Anti-arrhythmic effect of indomethacin in experimental studies].
V M Sambelian et al.
Kardiologiia, 28(2), 88-90 (1988-02-01)
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