07-1491
Anti-Calcineurin pan A Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform, calcineurin A alpha, protein phosphatase 3 (formerly 2B), catalytic subunit,
alpha isoform, protein phosphatase 3 (formerly 2B), catalytic subunit,
alp
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
100
200
conjugate
conjugate
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
liquid
purified by
affinity chromatography
species reactivity
human, rat, mouse
species reactivity (predicted by homology)
mammals (based on 100% sequence homology)
technique(s)
western blot: suitable
immunogen sequence
KLH-conjugated synthetic peptide corresponding to Calcineurin.
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
General description
Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin′s multifunctional capabilities in the regulation of calcium signaling.
Specificity
This antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species.
Immunogen
KLH-conjugated synthetic peptide corresponding to Calcineurin.
Application
Detect Calcineurin pan A using this Anti-Calcineurin pan A Antibody validated for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
GPCR, cAMP/cGMP & Calcium Signaling
Quality
Evaluated by Western Blot in Mouse brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.
Target description
~58 kDa
Linkage
Replaces: AB1695
Physical form
Affinity purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative.
Storage and Stability
Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
remain unfrozen.
remain unfrozen.
Analysis Note
Control
Mouse brain lysate
Mouse brain lysate
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Brain and behavior, 6(6), e00470-e00470 (2016-05-03)
Phospholamban (PLN) and sarcolipin (SLN) are small inhibitory proteins that regulate the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) pump. Previous work from our laboratory revealed that in the soleus and gluteus minimus muscles of mice overexpressing PLN (Pln (OE)), SERCA function was
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