592277

2-Chlorobenzimidazole

98%

• Empirical Formula (Hill Notation): C₇H₅ClN₂
• CAS Number: 4857-06-1
• Molecular Weight: 152.58
• EC Number: 225-453-3
• MDL number: MFCD00051944
• UNSPSC Code: 12352100
• eCl@ss: 32151902
• PubChem Substance ID: 24881379
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 98%
• form: solid
• mp: 207-211 °C (lit.)
• SMILES string: Clc1nc2ccccc2[nH]1
• InChI: 1S/C7H5ClN2/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H,(H,9,10)
• InChI key: AYPSHJCKSDNETA-UHFFFAOYSA-N

Description

General description

2-Chlorobenzimidazole can be synthesized by reacting benzimidazole-2-one with phosphoryl chloride in the presence of phenol.

Application

2-Chlorobenzimidazole can be used to synthesize the following:

• 1-methyl-2-chlorobenzimidazole via reaction with dimethyl sulfate
• 1-ethyl-2-chlorobenzimidazole via reaction with diethyl sulfate
• 1-benzyl-2-chlorobenzimidazole via reaction with benzyl chloride
• 2-chloro-4,5,6,7-tetrabromobenzimidazole via bromination with bromine

It may be used as a building block to synthesize 4-amino-6-benzimidazole-pyrimidines.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves