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Sigma-Aldrich

2-Chloro-5-methylpyridine

97%

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About This Item

Empirical Formula (Hill Notation):
C6H6ClN
CAS Number:
18368-64-4
Molecular Weight:
127.57
EC Number:
418-050-0
MDL number:
MFCD00792460
UNSPSC Code:
12352100
PubChem Substance ID:
24872966
NACRES:
NA.22

Assay

97%

refractive index

n20/D 1.53 (lit.)

bp

97 °C/30 mmHg (lit.)

density

1.169 g/mL at 25 °C (lit.)

SMILES string

Cc1ccc(Cl)nc1

InChI

1S/C6H6ClN/c1-5-2-3-6(7)8-4-5/h2-4H,1H3

InChI key

VXLYOURCUVQYLN-UHFFFAOYSA-N

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General description

2-Chloro-5-methylpyridine is a pesticide intermediate. Its synthesis by many methods has been reported.

Application

2-Chloro-5-methylpyridine may be used in the synthesis of:
  • 2-methylthio-5-pyridinemethylene amine
  • 5-methyl-2,2′-bipyridine
  • 1-(5′-methyl-2,2′-bipyridin-5-yl)-2,5-dimethyl-1H-pyrrole

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312,H315,H412

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synthesis of Differently Disubstituted 2,2'-Bipyridines by a Modified Negishi Cross-Coupling Reaction.
Lutzen A, et al.
European Journal of Organic Chemistry, 2003(20), 3948-3957 (2003)
The preparation of 2-chloro-5-methyl-pyridine in airlift loop reactor.
Jianping W, et al.
Chemical Engineering Journal, 95(1), 33-36 (2003)
Synthesis and herbicidal activity of (Z)-ethoxyethyl 2-cyano-3-(2-methylthio-5-pyridylmethylamino) acrylates.
Wang QM, et al.
Heteroatom Chem., 15(1), 67-70 (2004)
Synthesis of 5-Substituted 2,2'-Bipyridines from Substituted 2-Chloropyridines by a Modified Negishi Cross-Coupling Reaction.
Lutzen A and Hapke M.
European Journal of Organic Chemistry, 2002(14), 2292-2297 (2002)

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