- Isoserine-based biotinylated photoaffinity probes that interact with penicillin-binding protein 1b.
Isoserine-based biotinylated photoaffinity probes that interact with penicillin-binding protein 1b.
Chemical communications (Cambridge, England) (2002-08-13)
Thomas Rühl, Daniela Volke, Katherina Stembera, Yasumaru Hatanaka, Horst Hennig, Frank Schumer, Peter Welzel
PMID12170816
RÉSUMÉ
The photolytic decomposition of trifunctional carbene generating photoaffinity probes in methanolic solution was studied, a cleavage reaction with butylamine in water, the conjugation with a ligand (moenomycin), and experiments that demonstrate that the fully armed probes interact with penicillin-binding protein 1b.
MATÉRIAUX