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1249406

USP

Escitalopram oxalate

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

S-(+)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile oxalate, S-(+)-Citalopram oxalate

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About This Item

Formule empirique (notation de Hill):
C20H21FN2O · C2H2O4
Numéro CAS:
219861-08-2
Poids moléculaire :
414.43
Numéro MDL:
MFCD06407826
Code UNSPSC :
41116107
ID de substance PubChem :
329749746
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

escitalopram, escitalopram

Fabricant/nom de marque

USP

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

OC(=O)C(O)=O.CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c3ccc(F)cc3

InChI

1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6)/t20-;/m0./s1

Clé InChI

KTGRHKOEFSJQNS-BDQAORGHSA-N

Informations sur le gène

human ... SLC6A4(6532)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Escitalopram oxalate, the S-enantiomer of racemic citalopram, belongs to the class of compounds known as antidepressants, that works as a selective serotonin-reuptake inhibitor (SSRI).

Application

Escitalopram oxalate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Escitalopram Oral Solution
  • Escitalopram Oxalate
  • Escitalopram Tablets

Actions biochimiques/physiologiques

Escitalopram is a selective serotonin reuptake inhibitor (SSRI), the S-enantiomer and eutomer of citalopram.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302 + H312

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Spectrophotometric and reversed-phase high-performance liquid chromatographic methods for simultaneous determination of escitalopram oxalate and clonazepam in combined tablet dosage form
Gandhi VS, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 91(1), 33-38 (2008)
Application Of Stability Indicating Hptlc Method For Quantitative Determination Of Escitalopram Oxalate In Pharmaceutical Dosage Form.
Mahadik VM, et al.
Eurasian Journal of Analytical Chemistry, 2(2) (2007)
Simultaneous HPTLC determination of escitalopram oxalate and clonazepam in combined tablets.
Dhavale N, et al.
Chromatographia, 67(5-6), 487-490 (2008)
Dietmar Hestermann et al.
Behavioural brain research, 273, 155-165 (2014-07-22)
Serotonergic (5-HT) drugs are widely used in the clinical management of mood and anxiety disorders. However, it is reported that acute 5-HT treatment elicits anxiogenic-like behavior. Interestingly, the periaqueductal gray (PAG), a midbrain structure which regulates anxiety behavior - has
Kristan A Leech et al.
Journal of neurotrauma, 31(15), 1334-1342 (2014-04-20)
Incomplete spinal cord injury (iSCI) often results in significant motor impairments that lead to decreased functional mobility. Loss of descending serotonergic (5HT) input to spinal circuits is thought to contribute to motor impairments, with enhanced motor function demonstrated through augmentation
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