V116

Z-VAD-FMK

≥98% (TLC), solid, Caspase inhibitor

• Synonyme(s) : N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone
• Formule empirique (notation de Hill): C₂₂H₃₀FN₃O₇
• Numéro CAS: 187389-52-2
• Poids moléculaire : 467.49
• Numéro MDL: MFCD01074990
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.77

Propriétés

• Nom du produit: Z-VAD-FMK, solid
• Source biologique: synthetic
• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: solid
• Couleur: white
• Solubilité: DMSO: 20 mg/mL; H₂O: insoluble
• Température de stockage: −20°C
• Chaîne SMILES: FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC
• InChI: 1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
• Clé InChI: MIFGOLAMNLSLGH-QOKNQOGYSA-N
• Informations sur le gène: human ... CASP3(836) ; mouse ... CASP3(12367) ; rat ... CASP3(25402)

Description

Description générale

Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase). It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.

Application

Z-VAD-FMK has been used:

• to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells
• to induce autophagy in Jurkat and K562 cells
• to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines
• as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53

Actions biochimiques/physiologiques

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

Caractéristiques et avantages

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Attention

Hygroscopic

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)