UC160

4-Hydroxytolbutamide

≥98% (HPLC)

• Synonyme(s) : N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide
• Formule empirique (notation de Hill) : C₁₂H₁₈N₂O₄S
• Numéro CAS: 5719-85-7
• Poids moléculaire : 286.35
• NACRES: NA.77
• PubChem Substance ID: 24724642
• UNSPSC Code: 12161501
• MDL number: MFCD00144466
• Assay: ≥98% (HPLC)
• Form: solid

Propriétés

• assay: ≥98% (HPLC)
• form: solid
• color: white
• mp: 100-102 °C
• solubility: ethanol: soluble 12 mg/mL, 0.1 M NaOH: soluble 4 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: CCCCNC(=O)NS(=O)(=O)c1ccc(CO)cc1
• InChI: 1S/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)
• InChI key: SJRHYONYKZIRPM-UHFFFAOYSA-N

Description

Application

4-Hydroxytolbutamide has been used as a standard to assay the fungal biotransformation of tolbutamide to 4′-hydroxytolbutamide.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

4-Hydroxytolbutamide is soluble in ethanol at 12 mg/mL and is also soluble in 0.1 M NaOH at 4 mg/ml. It is insoluble in water.

Other Notes

Metabolite of tolbutamide; formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): Eyeshields, Gloves, type N95 (US)