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T1573

Sigma-Aldrich

Thrombin Receptor Activator Peptide 6

>95% (HPLC)

Synonyme(s) :

TRAP-6

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About This Item

Formule empirique (notation de Hill):
C34H56N10O9
Numéro CAS:
141136-83-6
Poids moléculaire :
748.87
Numéro MDL:
MFCD00238172
Code UNSPSC :
12352200
ID de substance PubChem :
329826680
Nomenclature NACRES :
NA.77

Niveau de qualité

200

Pureté

>95% (HPLC)

Forme

lyophilized

Technique(s)

cell culture | mammalian: suitable

Solubilité

0.1% TFA: soluble
water: soluble

Numéro d'accès UniProt

P25116

Température de stockage

−20°C

Chaîne SMILES 

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

InChI

1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1

Clé InChI

HAGOWCONESKMDW-FRSCJGFNSA-N

Informations sur le gène

human ... F2R(2149)

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn

Description générale

Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.

Application

Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).

Actions biochimiques/physiologiques

Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC50 = 0.8 μM).

Autres remarques

Lyophilized from 0.1% TFA in H2O

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Consulter la Bibliothèque de documents

Xavier Charest-Morin et al.
Frontiers in immunology, 9, 2183-2183 (2018-10-20)
Multiple pathways have been proposed to generate bradykinin (BK)-related peptides from blood. We applied various forms of activation to fresh blood obtained from 10 healthy subjects or 10 patients with hereditary angioedema (HAE-1 or -2 only) to investigate kinin formation.
Saskia Wand et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 24(1), 179-185 (2017-03-18)
We aimed to identify the prevalence of acetylsalicylic acid (ASA) nonresponse in patients after coronary artery bypass graft (CABG) surgery and the possible consequences for the rate of major cardiovascular events. This prospective, observational, bicentric cohort study was conducted in
Hematology: Basic Principles and Practice E-Book: Basic Principles and Practice (2017)
Kristoffer Navred et al.
PloS one, 14(1), e0211130-e0211130 (2019-01-24)
Flow cytometric platelet activation has emerged as an alternative diagnostic test for inherited platelet disorders. It is, however, labor intensive and few studies have directly compared the performance of flow cytometric platelet activation (PACT) to light transmission aggregometry (LTA). The
Juergen Koessler et al.
PloS one, 12(11), e0188193-e0188193 (2017-11-21)
Platelets are important for effective hemostasis and considered to be involved in pathophysiological processes, e.g. in cardiovascular diseases. Platelets provided for research or for therapeutic use are frequently separated from citrated whole blood (WB) stored for different periods of time.
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