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SRP8003

Sigma-Aldrich

Clusterin (nuclear form) mouse

>90% (SDS-PAGE), recombinant, expressed in E. coli, His tagged, liquid

Synonyme(s) :

Apolipoprotein J, CLI, Lymphocyte antigen 52 (Ly-52), SGP-2, TRPM-2

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

product name

Clusterin (nuclear form) mouse, recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

Source biologique

mouse

Produit recombinant

expressed in E. coli

Étiquette/Marqueur

His tagged

Pureté

>90% (SDS-PAGE)

Forme

liquid

Poids mol.

~45 kDa by SDS-PAGE

Conditionnement

pkg of 50 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Concentration

≥0.2 mg/mL

Impuretés

<1 EU/μg endotoxin, tested

Couleur

clear

Numéro d'accès UniProt

Q06890

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

mouse ... Clu(12759)

Description générale

Clusterin is expressed in all tissues. However, it is strongly expressed in the central nervous system and plasma. Clusterin mainly protects against heat and other stress. It is also referred as chaperone protein and stress-inducible biomarker. Clusterin exists in two isoforms, one is a secretory form and other is a nuclear form. The secreted form of the protein is a 80kDa disulfide-linked heterodimer of α and β subunits (produced by internal cleavage). The alternatively spliced inactive cytosolic form is changed to a truncated mature nuclear isoform via ionizing irradiation.

Actions biochimiques/physiologiques

Clusterin is involved in tissue remodeling, cell death, lipid transport, complement-associated cell lysis, cancer and neurological damage. It is strongly expressed in Alzheimer′s and treatment-resistant cancer. High levels of clusterin are observed in ischemic heart disease and diabetic conditions. It also protects kidney from fibrosis. Nuclear form of clusterin works as a pro-death signal, and suppresses cell growth and survival. The secreted form of clusterin has extracellular chaperone and anti-apoptotic activities.

Forme physique

Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.

Autres remarques

Mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Clusterin Modulates Allergic Airway Inflammation by Attenuating CCL20-Mediated Dendritic Cell Recruitment.
Hong GH, et al.
Journal of Immunology, 196, 2021-2021 (2001)
Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells.
Caccamo AE, et al.
Cell Death and Differentiation, 12, 101-101 (2005)
Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis.
Byun K, et al.
The Embo Journal, 15, 801-801 (2014)
Synthesis and functional analyses of nuclear clusterin, a cell death protein.
Leskov KS, et al.
The Journal of Biological Chemistry, 278, 11590-11590 (2003)
Clusterin is a potential lymphotoxin beta receptor target that is upregulated and accumulates in germinal centers of mouse spleen during immune response.
Afanasyeva MA, et al.
PLoS ONE, 9, e98349-e98349 (2014)
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