Accéder au contenu
Merck
Toutes les photos(1)

Documents

SRP4135

Sigma-Aldrich

IL-3 from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonyme(s) :

HCGF P-cell stimulation factorIL-3 MGC79398, Interleukin-3, MCGF (Mast cell growth factor)Multi-CSF, MGC79399

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Numéro MDL:
MFCD00164817
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

mouse

Produit recombinant

expressed in E. coli

Pureté

≥98% (HPLC)
≥98% (SDS-PAGE)

Forme

lyophilized

Puissance

<0.05 ng/mL ED50

Poids mol.

~15.1 kDa

Conditionnement

pkg of 10 μg

Impuretés

endotoxin, tested

Numéro d'accès NCBI

P01586

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

mouse ... Il3(16187)

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Description générale

IL3 (interleukin 3) is an immunomodulatory cytokine and a multilineage hematopoietic growth factor. It is predominantly produced by activated CD4+ T cells and mast cells. Recombinant mouse IL-3 is a 15.1 kDa protein containing 135 amino acid residues.

Actions biochimiques/physiologiques

IL3 (interleukin 3) was originally known as multicolony-stimulating factor due to its capability to promote the development of a wide variety of hematopoietic progenitor cells from bone marrow, such as basophils, neutrophils, eosinophils, erythrocytes, megakaryocytes, mast cells, macrophages, and dendritic cells. In vitro this protein facilitates murine hematopoietic progenitor cell differentiation, and the survival and activation of mature myeloid cells. It promotes the release of histamine and mast cell growth, differentiation, and mediator release, and hence, is implicated in allergic inflammation. It exhibits bi-functionality during osteoclastogenesis where it stimulates the development of osteoclast progenitors but suppresses the osteoclastogenic process. Certain variants in this gene confer protection against malaria attack, and thus, this gene might play a role in the pathophysiology of falciparum malaria.

Forme physique

Sterile filtered and lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1 –1.0 mg/mL. The solution can then be diluted into other aqueous buffers.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks.
Meyer CG, et al.
Human Molecular Genetics, 20(6), 1173-1181 (2011)
Interleukin-3-deficient mice have increased resistance to blood-stage malaria.
Auclair SR et al
Infection and Immunity, 82(3), 1308-1314 (2014)
Jing Wang et al.
EMBO molecular medicine, 6(7), 952-969 (2014-06-26)
Immunoglobulin E (IgE) activates mast cells (MCs). It remains unknown whether IgE also activates other inflammatory cells, and contributes to the pathogenesis of abdominal aortic aneurysms (AAAs). This study demonstrates that CD4+ T cells express IgE receptor FcεR1, at much
Serena De Vita et al.
PloS one, 9(5), e96209-e96209 (2014-05-03)
Systemic Mastocytosis (SM) is a clonal disease characterized by abnormal accumulation of mast cells in multiple organs. Clinical presentations of the disease vary widely from indolent to aggressive forms, and to the exceedingly rare mast cell leukemia. Current treatment of
Huixian Hong et al.
Biochemical and biophysical research communications, 440(4), 545-550 (2013-10-10)
Interleukin (IL)-3, a multilineage hematopoietic growth factor, is implicated in the regulation of osteoclastogenesis. However, the role of IL-3 in osteoclastogenesis remains controversial; whereas early studies showed that IL-3 stimulates osteoclastogenesis, recent investigations demonstrated that IL-3 inhibits osteoclast formation. The
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique